A membrane-bound nuclease directly cleaves phage DNA during genome injection

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Agar’s low viscosity also makes it easy to pour into Petri dishes, and its transparency permits observation of microbes growing on its surface.7 Also aiding in this is its low syneresis (extrusion of water from the gel), guaranteeing less surface “sweating”: Once a plate is inoculated, bacterial colonies stay in place and do not mix.

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What's newI used to recommend the M4 MacBook Pro as a cheaper alternative to the M5 model, but as of February 2026, it's no longer available in new condition at any third-party retailers. (The Apple Store discontinued it right when the M5 MacBook Pro came out.) As such, I've removed all mentions of it from this guide.

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